Global and regional left ventricular function and tomographic radionuclide perfusion: the Western Washington Intracoronary Streptokinase In Myocardial Infarction Trial

Journal Article · Wed Oct 31 23:00:00 EST 1984 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.70.5.867· OSTI ID:5948377

Ritchie, J L; Davis, K B; Williams, D L; Caldwell, J; Kennedy, J W

The Western Washington Intracoronary Streptokinase In Myocardial Infarction Trial enrolled 250 patients with acute myocardial infarction. After the coronary angiographic diagnosis of thrombosis, patients were randomly assigned to receive either conventional therapy with heparin or intracoronary streptokinase followed by heparin. Of the 232 patients who survived at least 60 days, 207 (89%) underwent radionuclide ventriculographic determination of global and regional ejection fraction at a single institution at 62 +/- 35 days after infarction. In the first 100 patients, infarct size was also determined by quantitative single-photon emission tomographic imaging with thallium-201 (/sup 201/Tl) and expressed as a percentage of the left ventricle with a perfusion defect. Overall, global ejection fraction did not differ between patients treated with streptokinase (45.9 +/- 13.9%; n . 115) and control patients (46.1 +/- 14.4%; n . 92, p . NS). Similarly, the regional posterolateral, inferior, and anteroseptal ejection fraction did not differ between the two groups. Infarct size as measured by /sup 201/Tl tomography was 19.4 +/- 12.8% (n . 52) of the left ventricle for the streptokinase group and 19.6 +/- 11.8% (n . 48; p . NS) for the control group. When patients were compared within groups by electrocardiographic location of infarction, time to treatment, or the presence or absence of vessel opening, there were no significant differences between streptokinase and control patients. Statistical inclusion of the 18 patients who died early and were unavailable for study also failed to modify the results, except for a possible reduction in inferior infarct size as measured by /sup 201/Tl tomography.

• Research Organization: Veterans Administration Medical Center, Seattle, WA
• OSTI ID: 5948377
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 70:5; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANTICOAGULANTS
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENZYMES
HEART
HEAVY NUCLEI
HEMATOLOGIC AGENTS
HEPARIN
HYDROLASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MATHEMATICS
MEDICINE
MUCOPOLYSACCHARIDES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HYDROLASES
POLYSACCHARIDES
RADIOISOTOPES
RADIOLOGY
REGRESSION ANALYSIS
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
SH-PROTEINASES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STATISTICS
STREPTOCOCCAL PROTEINASE
SURVIVAL TIME
THALLIUM 201
THALLIUM ISOTOPES
THERAPY
THROMBOSIS
TOMOGRAPHY
TRACER TECHNIQUES
VASCULAR DISEASES