Response of left ventricular volume to exercise in man assessed by radionuclide equilibrium angiography. [/sup 99m/Tc-human serum albumin]

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.60.3.565· OSTI ID:5945287

Slutsky, R; Karliner, J; Ricci, D; Schuler, G; Pfisterer, M; Peterson, K; Ashburn, W

To assess the effects of exercise on left ventricular volumes we studied 10 normal men, 15 patients with coronary disease who developed angina pectoris during exercise, and 10 patients with known coronary disease who did not develop angina during exercise. Each subject performed supine bicycle exercise under a mobile, single-crystal scintillation camera until angina or fatigue occurred. Technetium-99m bound to human serum albumin was the imaging agent. Data were collected at rest and during the last 2 minutes of each 3-minute stage of exercise and for 10 minutes after exercise. Volumes were calculated by a new radionuclide technique that correlated well with cineangiography and is expressed in nondimensional units. In normal subjects, the end-diastolic volume (EDV) at rest was not different from that a peak exercise. The end-systolic volume (ESV) decreased at peak exercise. ESV decreased progressively in all but two of 30 exercise periods. Angina patients had a larger EDV at rest and during chest pain than normals. Angina patients increased their ESV during chest pain resulting in a decreased ejection fraction (EF). All angina patients had a higher ESV during chest pain than during the exercise stage before chest pain. As a group, patients who did not develop angina had a lower EDV at rest and peak exercise than those who did develop angina. We conclude: that the EF increases during exercise due to a decrease in ESV; that the EF in patients with angina decreases because of an increase in ESV; and that the EF in coronary disease patients without angina shows no change because there is no significant change in the ESV. Radionuclide equilibrium angiography may prove useful for assessing EF and volume changes in patients with coronary artery disease.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 5945287
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 60:3; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EXERCISE
EXPERIMENTAL DATA
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEASURING METHODS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VOLUME
YEARS LIVING RADIOISOTOPES