Reporter molecules as probes of DNA conformation: structure of a crystalline complex containing 2-methyl-4-nitro-aniline ethylene dimethylammonium hydrobromide - 5-iodocytidylyl(3'-5')guanosine
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
2-Methyl-4-nitroaniline ethylene dimethylammonium hydrobromide forms a crystalline complex with the self-complementary dinucleoside monophosphate, 5-iodocytidylyl(3'-5')guanosine. The crystals are tetragonal, with a = b = 32.192 A and c = 23.964 A, space group P4/sub 3/2/sub 1/2. The structure has been solved to atomic resolution by Patterson and Fourier methods, and refined by full matrix least squares. 5-Iodocytidylyl(3'-5')guanosine molecules are held together in pairs through Watson-Crick base-pairing, forming an antiparallel duplex structure. Nitroaniline molecules stack above and below guanine-cytosine pairs in this duplex structure. In addition, a third nitroaniline molecule stacks on one of the other two nitroaniline molecules. The asymmetric unit contains two 5-iodocytidylyl(3'-5')guanosine molecules, three nitroaniline molecules, one bromide ion and thirty-one water molecules, at total of 160 atoms. Details of the structure are described. 15 references, 4 figures, 2 tables.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, NY
- OSTI ID:
- 5944259
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 121:1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
AZAARENES
BROMINE COMPLEXES
COMPLEXES
CRYSTALS
DATA
DNA
EXPERIMENTAL DATA
GUANOSINE
HETEROCYCLIC COMPOUNDS
INFORMATION
LEAST SQUARE FIT
MAXIMUM-LIKELIHOOD FIT
MOLECULAR STRUCTURE
MOLECULES
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PURINES
RIBOSIDES
59 BASIC BIOLOGICAL SCIENCES
AROMATICS
AZAARENES
BROMINE COMPLEXES
COMPLEXES
CRYSTALS
DATA
DNA
EXPERIMENTAL DATA
GUANOSINE
HETEROCYCLIC COMPOUNDS
INFORMATION
LEAST SQUARE FIT
MAXIMUM-LIKELIHOOD FIT
MOLECULAR STRUCTURE
MOLECULES
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PURINES
RIBOSIDES