Thallium-201 scintigraphy in differentiated thyroid cancer: Comparison with radioiodine scintigraphy and serum thyroglobulin determinations

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5944193

Ramanna, L; Waxman, A; Braunstein, G ^[1]

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1. Cedars-Sinai Medical Center, Los Angeles, CA (USA)

The role of thallium-201 ({sup 201}TI) scintigraphy in the follow-up evaluation of differentiated thyroid carcinoma (DTC) is controversial. Desirable characteristics of {sup 201}TI scintigraphy including the potential for no thyroid hormone withdrawal, immediate imaging postinjection, and low radiation burden relative to iodine-131 ({sup 131}I) suggests it is logistically superior to {sup 131}I scintigraphy. Fifty-two patients with DTC were evaluated with {sup 201}TI and {sup 131}I neck and chest images, and serum thyroglobulin measurements. In post-thyroidectomy and pre-{sup 131}I ablation therapy patients, very little {sup 201}TI accumulation was noted within the thyroid bed, with discordantly increased {sup 131}I activity and normal serum thyroglobulin measurements. Twenty-nine percent of patients evaluated after {sup 131}I ablative therapy had elevated serum thyroglobulin levels and localized neck and chest abnormalities on 201TI scan that were not seen on {sup 131}I studies. Our data suggest that {sup 201}TI is more sensitive than {sup 131}I diagnostic (5 mCi) studies for detection of DTC, while {sup 131}I is more sensitive in detecting normal residual thyroid tissue postoperatively.

• OSTI ID: 5944193
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:3; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
CARCINOMAS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ENDOCRINE GLANDS
GLANDS
GLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SYNTHESIS
THYROGLOBULIN
THYROID