Rapid gas chromatographic determination of ethylene oxide, ethylene chlorohydrin, and ethylene glycol residues in rubber catheters

Journal Article · · J. Assoc. Off. Anal. Chem.; (United States)

OSTI ID:5940702

Muzeni, R J

Isothermal gas chromatography with flame ionization detection was used to determine residual ethylene oxide (EtO), ethylene chlorohydrin, and ethylene glycol in soft rubber catheters that had been sterilized with EtO. Catheter samples were extracted by shaking with carbon disulfide, and the extract was analyzed on a 3% Carbowax 20M on 80-100 mesh Chromosorb 101 column, using nitrogen as the carrier gas. Ten replicate injections of a mixed standards solution gave coefficients of variation of 1.91, 1.23, and 4.74% for EtO, ethylene chlorohydrin, and ethylene glycol, respectively. A linear response was obtained with concentrations ranging from 1.0 to 7.9 ..mu..g EtO, 14.0 to 88.0 ..mu..g ethylene chlorohydrin, and 31.0 to 98.5 ..mu..g ethylene glycol. The proposed method detected as little as 0.5, 5.0, and 16.5 ng EtO, ethylene chlorohydrin, and ethylene glycol, respectively.

• Research Organization: Food and Drug Administration, Brooklyn, NY
• OSTI ID: 5940702
• Journal Information: J. Assoc. Off. Anal. Chem.; (United States), Journal Name: J. Assoc. Off. Anal. Chem.; (United States) Vol. 68:3; ISSN JANCA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALKENES
AROMATICS
CHALCOGENIDES
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
ELASTOMERS
ETHYLENE
GAS CHROMATOGRAPHY
GLYCOLS
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
HYDROXY COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
OXIDES
OXYGEN COMPOUNDS
POLYMERS
RUBBERS
SEPARATION PROCESSES