Bone scintigraphy in fluoride treated osteoporosis
Quantitative bone scintigraphy was performed on 23 white females with post-menopausal osteoporosis and vertebral compression fractures. These patients were then entered into a randomized, double-blind clinical trial or sodium fluoride therapy (NaF=14, placebo=9) which included repeat bone scintigraphy every six months. Scintigraphic images were acquired for 500K counts per image over the total body with computer acquisition over the posterior thoracic and lumbar spine. Images were obtained on a wide field-of-view gamma camera two hours after injecting 15 mCi of Tc-99m MDP. Data analysis showed a significant reduction in the activity ratio of abnormal vertebral body to normal vertebral body in those patients treated with sodium fluoride (paired t-test p=0.0095). No significant change was observed in the control group of (p=0.142). These results suggest that sodium fluoride therapy promotes more rapid healing of osteoporotic vertebral fractures. They also demonstrate the utility of serial quantitative bone scintigraphy in assessing osteoporotic patients with vertebral compression fractures.
- Research Organization:
- Henry Ford Hospital, Detroit, MI
- OSTI ID:
- 5938849
- Report Number(s):
- CONF-850611-; TRN: 87-039277
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE FRACTURES
CHEMOTHERAPY
HEALING
BONE TISSUES
SCINTISCANNING
OSTEOPOROSIS
SODIUM FLUORIDES
THERAPEUTIC USES
DATA ACQUISITION SYSTEMS
DATA ANALYSIS
FEMALES
IMAGE PROCESSING
PATIENTS
ALKALI METAL COMPOUNDS
ANIMAL TISSUES
BIOLOGICAL RECOVERY
BODY
CONNECTIVE TISSUE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
FLUORIDES
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
INJURIES
PROCESSING
RADIOISOTOPE SCANNING
RECOVERY
SKELETAL DISEASES
SODIUM COMPOUNDS
THERAPY
TISSUES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551000 - Physiological Systems
551001 - Physiological Systems- Tracer Techniques