Factors that influence the suppression of pulmonary antibacterial defenses in mice exposed to ozone
Exposure to ozone (O3) has been shown to increase susceptibility of mice to bacterial infection; however, the underlying mechanism has not been well elucidated. The study investigated the effect of O3 exposure on the ability of mice to combat an infectious challenge of Streptococcus zooepidemicus. Following a 3-h exposure to either air, 0.4 ppm O3, or 0.8 ppm O3, 5- and 9-week-old mice received an aerosol infection of bacteria. Intrapulmonary killing of the bacteria was impaired in the O3-exposed mice. The effect was most severe at the higher dose of O3 in the younger mice, and showed good correlation to subsequent mortality assessed over a 20-day period. Alveolar macrophages (AM) from O3-exposed mice had an impaired ability to phagocytose the bacteria. Additionally, prostaglandin E2 (PGE2) levels, which are known to depress AM function, were increased in the bronchoalveolar lavage fluid of the younger mice following exposure to O3, while pretreatment with indomethacin in the drinking water blunted the increased of PGE2 and reduced O3 enhanced mortality from 53 to 33%. The data show that O3 inhalation can reduce the defensive capability of the murine lung and that this is associated with a reduction in AM phagocytosis. (Copyright (c) 1993 Taylor Francis.)
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 5937546
- Report Number(s):
- PB-93-236354/XAB; EPA--600/J-93/398
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
BACTERIA
BIOLOGICAL EFFECTS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
DRINKING WATER
DRUGS
ENVIRONMENTAL EFFECTS
HYDROGEN COMPOUNDS
IMMUNOSUPPRESSION
INHALATION
INTAKE
LAVAGE
MACROPHAGES
MAMMALS
MICE
MICROORGANISMS
MORTALITY
OXYGEN COMPOUNDS
OZONE
PHAGOCYTES
PHAGOCYTOSIS
POLLUTION
PROSTAGLANDINS
RODENTS
SOLS
SOMATIC CELLS
STREPTOCOCCUS
VERTEBRATES
WATER