Prediction of radiation dosimetry in patients with thyroid cancer using a Gamma camera
Radioiodine in the thyroid or cervical metastases, and therefore radiation dosimetry, can be determined using a probe and phantom. This approach is not ideal for quantitating radioiodine and dosimetry for sites elsewhere in the body. The authors have studied the use of gamma camera methods in association with I-123 to predict the distribution of I-131 and its dosimetry in 3 patients with metastatic thyroid cancer. Images and urine were obtained after administration of tracer I-123 and treatment I-131 to each patient. The geometric mean of counts from anterior and posterior total body camera scans were used to determine body clearance. Organ or metastasis radioactvity and dosimetry were quantitated using planar images and SPECT. Uptake, clearance and dosimetry of structures, such as thyroid and nodular metastases in the lung, could be determined. In summary, a gamma camera method for improved quantitation of radioiodine distribution in the body has been explored. It provides quantitative pharmacokinetics which give better estimates of distribution of radiation dose. This information offers a less empirical approach to the treatment of thyroid cancer with I-131, and other cancers with radiolabeled antibodies.
- Research Organization:
- Univ. of California Davis Medical Center, Sacramento, CA
- OSTI ID:
- 5935532
- Report Number(s):
- CONF-850611-; TRN: 87-039620
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IODINE 123
DOSIMETRY
THERAPEUTIC USES
TISSUE DISTRIBUTION
IODINE 131
NEOPLASMS
RADIOTHERAPY
THYROID
RADIATION DOSES
GAMMA CAMERAS
GAMMA DOSIMETRY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CAMERAS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
THERAPY
TOMOGRAPHY
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)