New biological dimensions in mass spectrometry
Journal Article
·
· Biotechniques; (United States)
OSTI ID:5932796
Major advances in the field of mass spectrometry are of significant interest to the biologist searching for new analytical methods. Three frontiers of particular interest are fast atom bombardment (FAB), combined liquid chromatography/mass spectrometry (LC/MS), and mass spectrometry/mass spectrometry (MS/MS). Mass spectra of such large, nonvolatile, and thermally labile compounds as peptides, saccharides, antibiotics, nucleotides, etc. are now obtained routinely. The authors discuss the basis for FAB, LC/MS, and MS/MS and gives examples of each as applied to biological problems. Of special interest is the use of these methods to provide sequence information on small bio-oligomers, including peptides and oligonucleotides. 49 references, 5 figures.
- Research Organization:
- Indiana Univ., Bloomington
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5932796
- Journal Information:
- Biotechniques; (United States), Journal Name: Biotechniques; (United States)
- Country of Publication:
- United States
- Language:
- English
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