Proteins encoded near the adenovirus late messenger RNA leader segments

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Virology; (United States)

DOI:https://doi.org/10.1016/0042-6822(83)90376-8· OSTI ID:5932127

Lewis, J B; Anderson, C W

Small fragments of adenovirus 2 DNA cloned into the single-strand phage M13 were used to select adenoviral messenger RNAs transcribed from the R-strand between map positions 16 and 30. Cell-free translation of these mRNAs produced proteins of 13.5K, 13.6K, and 11.5K, respectively encoded between the first and second segments of the tripartite major late leader, within the ''i''-leader segment, and immediately preceding the third leader segment. Partial sequence analysis of the 13.6K protein is consistent with the hypothesis that it is encoded within the i-leader segment.

• Research Organization: Fred Hutchinson Cancer Research Center, Seattle, WA
• OSTI ID: 5932127
• Journal Information: Virology; (United States), Journal Name: Virology; (United States) Vol. 127; ISSN VIRLA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ADENOVIRUS
AMINO ACID SEQUENCE
BACTERIOPHAGES
CLONING
DNA
GENETIC MAPPING
HYBRIDIZATION
MAPPING
MESSENGER-RNA
MICROORGANISMS
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PEPTIDES
POLYPEPTIDES
PROTEINS
RNA
TRANSCRIPTION
VIRUSES