Experimental oral lead toxicity in young dogs
Litter-mate male pups were fed a calcium-and-phosphorus-low purified diet with and without 100 ppm of lead as lead acetate from age 6 to 18 weeks. Lead-toxic dogs exhibited cyclic but terminally severe anorexia and cachexia, significant anemia, normoblastocytosis and leukopenia within six weeks, hypoproteinemia, decreased serum albumin, ..cap alpha../sub 1/-globulin, ..beta../sub 2/-globulin, alkaline phosphatase and lactic dehydrogenase 1, elevated serum glutamic oxaloacetic and pyruvic transaminases, delayed closure of the thoracic vertebral epiphyses, lead lines in the distal radii and thoracic spinous processes, enlargement of liver, kidney, and brain, hepatic fatty metamorphosis, focal proximal renal tubular necrosis, hydropic degeneration of spermatognia, and lead inclusion body formation. Approximately 97% of the tissue lead was estimated to be skeletal; the greatest concentration of lead in the brain was found in the occipital gray matter.
- Research Organization:
- Univ. of North Carolina, Chapel Hill
- OSTI ID:
- 5928516
- Journal Information:
- Arch. Pathol.; (United States), Vol. 95
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DOGS
INJURIES
LEAD
BIOLOGICAL ACCUMULATION
TOXICITY
ANEMIAS
BRAIN
DIET
ENZYMES
INGESTION
KIDNEYS
LEUKEMIA
LIVER
TISSUE DISTRIBUTION
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELEMENTS
GLANDS
HEMIC DISEASES
INTAKE
MAMMALS
METALS
NEOPLASMS
NERVOUS SYSTEM
ORGANS
SYMPTOMS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)