Interaction of glucocorticoids with macrophages

Journal Article · Sun Jan 01 04:00:00 EST 1978 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.147.6.1684· OSTI ID:5926098

Werb, Z; Foley, R; Munck, A

The mononuclear phagocyte system plays a central role in mediating host responses in inflammation. Glucocorticoids have anti-inflammatory actions that may be of considerable importance in the therapeutic effects of these agents in chronic inflammation; it is possible that some of these effects are mediated through direct hormonal action on macrophages. Although the site of action of the glucocorticoids on macrophages has not been established, it has been shown that in many other glucocorticoid target systems the effects of glucocorticoids are mediated by specific macromolecular binding proteins, referred to as receptors. In this study we have established that monocytes and macophages contain saturable glucocorticoid-binding proteins, with specificity of binding for cortisol, corticosterone, and related synthetic steroids such as dexamethasone, and that they have dissociation constants for binding within physiological ranges.

• Research Organization: Univ. of Califorina, San Francisco
• OSTI ID: 5926098
• Journal Information: J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 147; ISSN JEMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMAL CELLS
BINDING ENERGY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
CORTICOSTERONE
DEXAMETHASONE
DISEASES
ENERGY
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INFLAMMATION
KETONES
LEUKOCYTES
MACROPHAGES
MONOCYTES
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
PREGNANES
PROTEINS
RECEPTORS
SOMATIC CELLS
STEROID HORMONES
STEROIDS