A protocol for bladder cancer screening and medical surveillance among high-risk groups: The Drake Health Registry experience

Journal Article · Sat Sep 01 04:00:00 EDT 1990 · JOM, Journal of Occupational Medicine; (USA)

DOI:https://doi.org/10.1097/00043764-199009000-00025· OSTI ID:5922922

Marsh, G M; Callahan, C; Pavlock, D; Leviton, L C; Talbott, E O; Hemstreet, G ^[1]

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1. Univ. of Pittsburgh, PA (USA)

In 1986, the Drake Health Registry Study initiated bladder cancer screening for 366 persons at high risk because of occupational exposure to beta-naphthylamine. The Drake Health Registry Study screening protocol consists of urinalysis, Papanicolaou cytology, and quantitative fluorescence image analysis. A positive screening test qualifies participants for a full diagnostic evaluation. The screening protocol has been modified during the first 3 years of the program's existence to address unexpected patterns of test results and to incorporate advances in screening technology. The current protocol, which has a two-tiered screening schedule, has been utilized successfully for 15 months. Of the 26 positive results to date most have been based on abnormal Papanicolaou cytology and/or quantitative fluorescence image analysis. Bladder abnormalities were cited among most of the 18 study members who underwent diagnostic evaluation, including chronic cystitis, inflammation, hyperplasia, and dysplasia. We conclude that the screening program is detecting very early changes in a relatively young cohort and that these persons must be monitored over a number of years to ensure adequate medical surveillance.

• OSTI ID: 5922922
• Journal Information: JOM, Journal of Occupational Medicine; (USA), Journal Name: JOM, Journal of Occupational Medicine; (USA) Vol. 32:9; ISSN 0096-1736; ISSN JJOMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BLADDER
BODY
CARCINOGENESIS
CHEMICAL INDUSTRY
CONDENSED AROMATICS
DISEASES
FLUORESCENCE
HYDROCARBONS
INDUSTRY
LUMINESCENCE
NAPHTHALENE
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERSONNEL
RISK ASSESSMENT
SCREENING
URINARY TRACT