A possible role of atrial natriuretic peptide in ethanol-induced acute diuresis

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90538-M· OSTI ID:5922531

Colantonio, D; Casale, R; Mammarella, M; Pasqualetti, P ^[1]; Desiati, P; De Michele, G ^[2]

---

1. Univ. of L'Aquila (Italy)
2. General Hospital of Coppito, L'Aquila (Italy)

The acute effects of ethanol on plasma atrial natriuretic peptide levels were investigated in 4 clinically healthy males, aged 24-26 years, consumed either 750 ml of water as a control study, or the same beverage with 1 ml/kg alcohol added, which increased the plasma alcohol concentration to 99.12{plus minus}15.10 mg/dl at 60 min. Plasma atrial natriuretic peptide levels were significantly higher in the alcohol study compared to the control study at each time point, and with a peak at 10 min. Atrial natriuretic peptide levels showed a positive significant correlation with plasma antidiuretic hormone in the control group, while no relationship was found between the two peptides in the alcohol study. Moreover, a significant correlation exists between plasma atrial natriuretic peptide levels and systolic arterial blood pressure, and heart rate, and between the variations in atrial natriuretic peptide values and the variations in plasma sodium, serum ethanol, and plasma osmolality in the alcohol study. Acute ethanol intake causes an increase in urinary volume, and a decrease in urinary potassium excretion and urinary osmolality, and no change in urinary sodium excretion.

• OSTI ID: 5922531
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:7; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD PLASMA
BLOOD PRESSURE
BODY FLUIDS
ELECTROLYTES
ETHANOL
HORMONES
HYDROXY COMPOUNDS
MAMMALS
MAN
MATERIALS
METABOLISM
ORGANIC COMPOUNDS
PEPTIDES
PRIMATES
PROTEINS
SYNTHESIS
VERTEBRATES