Percutaneous penetration of benzene and benzene contained in solvents used in the rubber industry

Journal Article · Tue Sep 01 00:00:00 EDT 1981 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1981.10667633· OSTI ID:5917110

Maibach, H I; Anjo, D M

Penetration of benzene through the skin of the rhesus monkey was determined using /sup 14/C-benzene, and quantitating the labelled metabolites in urine. The modes of application and amounts of benzene that penetrated the skin (indicated in parentheses) are as follows: (1) a single, direct cutaneous application of liquid benzene (0.172 +/- 0.139%); (2) a single application of benzene-containing (0.36%) solvent (0.0805 +/- 0.0306%); (3) multiple washes with full-strength benzene (0.848 +/- 0.0806%); (4) multiple washes with the benzene-containing (0.35%) solvent (0.431 +/- 0.258%); (5) removal of the stratum corneum followed by application of full-strength benzene (0.09 +/- 0.627%); and (6) application of benzene to the palmar surface (0.651 +/- 0.482%). Until more complete human data becomes available, benzene penetration in the monkey may be used to estimate penetration in man, both for industrial hygiene purposes and general toxicological use.

• OSTI ID: 5917110
• Journal Information: Arch. Environ. Health; (United States), Vol. 36:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZENE
BIOLOGICAL EFFECTS
CHEMICAL INDUSTRY
HEALTH HAZARDS
CARBON 14 COMPOUNDS
INDUSTRY
MONKEYS
QUANTITATIVE CHEMICAL ANALYSIS
RUBBERS
TOXICITY
URINE
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
ELASTOMERS
HAZARDS
HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
POLYMERS
PRIMATES
VERTEBRATES
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)