Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3578108· OSTI ID:5917016

Musk, S R ^[1]

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1. Institute of Cancer Research, Sutton, Surrey (England)

The effect of caffeine upon the radiosensitivities of three human tumor lines was examined and correlated with its action upon the radiation-induced S-phase and G2-phase blocks. Caffeine was found to reduce at least partially the S-phase and G2-phase blocks in all the cell lines examined but potentiated cytotoxicity in only one of the three tumor lines. That reductions have been demonstrated to occur in the absence of increased cell killing provides supporting evidence for the hypothesis that reductions may not be causal in those cases when potentiation of radiation-induced cytotoxicity is observed in the presence of caffeine.

• OSTI ID: 5917016
• Journal Information: Radiation Research; (USA), Vol. 125:3; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CAFFEINE
RADIOSENSITIVITY EFFECTS
TUMOR CELLS
RADIOSENSITIVITY
CELL CYCLE
CELL KILLING
COBALT ISOTOPES
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
IN VITRO
MAN
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
ISOTOPES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRIMATES
PURINES
RADIATIONS
VERTEBRATES
XANTHINES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture