Renal effects of renal x irradiation and induced autoallergic glomerulonephritis

Journal Article · Sat Sep 01 00:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575177· OSTI ID:5913086

Rappaport, D S; Casarett, G W

This study was conducted to determine what influence a single large x-ray exposure of kidney has on the development and course of an experimental autoallergic glomerulonephritis (EAG) in rats. EAG was induced in female Sprague-Dawley rats by immunization with Bordetella pertussis vaccine and homogenate of homologous kidney tissue and Freund's complete adjuvant. Progressive arteriolonephrosclerosis (ANS) was observed in right (irradiated) kidneys following unilateral renal irradiation (1500 rad). Rats were either immunized, sham-immunized, irradiated, sham-irradiated, or both immunized and irradiated. Light and immunofluorescent microscopic observation, urine protein content, and kidney weights were evaluated. In immunized-irradiated animals the effects of irradiation and immunization were largely additive. Immunization did not considerably influence the development and course of ANS and irradiation did not considerably influence the development and course of EAG.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, NY
• DOE Contract Number: UR-3490-1371
• OSTI ID: 5913086
• Journal Information: Radiat. Res.; (United States), Vol. 79:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
IMMUNITY
SYNERGISM
KIDNEYS
X RADIATION
BIOLOGICAL EFFECTS
NEPHRITIS
RATS
ANIMALS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATIONS
RODENTS
UROGENITAL SYSTEM DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology