/sup 99m/Tc-DPD uptake in juvenile hemarthrosis. Scintimetry and autoradiography of the knee in dogs

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Orthopedics (Thorofare, N.J.); (United States)

OSTI ID:5904081

Hansen, E S; Hjortdal, V E; Noer, I; Christensen, S B; Holm, I E; Buenger, C

The pathogenesis of subchondral bone lesions and growth plate affection in hemophilic arthropathy was studied in puppies by means of repeated regional /sup 99m/Tc-diphosphonate scintimetry and contact autoradiography. Unilateral hemarthrosis of the knee was induced by biweekly intraarticular injections of autologous blood for 12 weeks. Hemarthrosis caused an early (2 to 4 weeks) decrease in uptake of /sup 99m/Tc-diphosphonate in the juxtaarticular growth plates (ratio 0.7) and a delayed (8 to 10 weeks) increase in epiphyseal uptake (ratio 1.5). In a recovery phase after hemarthrosis, growth plate uptake returned to normal, while the epiphyseal uptake remained elevated for 8 to 10 weeks. By contact autoradiography, the growth plate uptake was localized to the calcification layer at the metaphyseal aspect of the growth plates, while the epiphyseal uptake mainly was seen in the thin subchondral and subsynovial bone layer and around osteophytes. The changes in uptake of /sup 99m/Tc-diphosphonate following hemarthrosis for 3 months were reversible and could be ascribed to the presence of synovial inflammation.

• Research Organization: Orthopedic Hospital, Aarhus (Denmark)
• OSTI ID: 5904081
• Journal Information: Orthopedics (Thorofare, N.J.); (United States), Journal Name: Orthopedics (Thorofare, N.J.); (United States) Vol. 12:3; ISSN ORTHD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTORADIOGRAPHY
BODY
BODY AREAS
BONE JOINTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ISOMERIC NUCLEI
LEGS
LIMBS
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIOISOTOPE SCANNING
SCINTISCANNING
SKELETAL DISEASES
SKELETON
VERTEBRATES