Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging
Iofetamine hydrochloride I-123 permits cerebral blood perfusion imaging with single photon emission computed tomography (SPECT). SPECT is more widely available than positron emission tomography, and complements anatomic visualization with X-ray computed tomography (CT) or magnetic resonance imaging. Iofetamine is an amphetamine analog that is rapidly taken up by the lungs, then redistributed principally to the liver and brain. The precise mechanism of localization has not been determined, but is believed to result from nonspecific receptor binding. Brain uptake peaks at 30 minutes postinjection and remains relatively constant through 60 minutes. The drug is metabolized and excreted in the urine, with negligible activity remaining at 48 hours. When compared with CT in stroke patients, visualization may be performed sooner after symptom onset and a larger zone of involvement may be evident with iofetamine. Localization of seizure foci and diagnosis of Alzheimer's disease may also be possible. As CT has revolutionized noninvasive imaging of brain anatomy, SPECT with iofetamine permits routine cerebral blood flow imaging. 36 references.
- Research Organization:
- Univ. of Cincinnati, OH (USA)
- OSTI ID:
- 5903823
- Journal Information:
- DICP; (United States), Vol. 23:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
I-123 Iofetamine SPECT scan in children with neurological disorders
I-123 iofetamine single photon emission tomography in school-age children with difficult-to-control seizures
Related Subjects
BRAIN
BLOOD FLOW
NERVOUS SYSTEM DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
EVALUATION
AMPHETAMINES
BLOOD CIRCULATION
BLOOD-BRAIN BARRIER
IODINE 123
METABOLISM
PERFUSED ORGANS
REVIEWS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SYMPATHOMIMETICS
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics