Mapping the x-linked lymphoproliferative syndrome
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.
- Research Organization:
- Boston Univ. School of Medicine, MA
- OSTI ID:
- 5903361
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:7; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Thu Sep 01 00:00:00 EDT 1994
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OSTI ID:186060
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OSTI ID:110959
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OSTI ID:134430
Related Subjects
550401* -- Genetics-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
AUTORADIOGRAPHY
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
DNA
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HETEROCHROMOSOMES
INFECTIOUS DISEASES
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PATIENTS
SOMATIC CELLS
VIRAL DISEASES
VIRUSES
X CHROMOSOME
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
AUTORADIOGRAPHY
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
DNA
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HETEROCHROMOSOMES
INFECTIOUS DISEASES
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PATIENTS
SOMATIC CELLS
VIRAL DISEASES
VIRUSES
X CHROMOSOME