Selective 2-( sup 18 F)fluorodopa uptake for melanogenesis in murine metastatic melanomas

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5893995

Ishiwata, K; Kubota, K; Kubota, R; Iwata, R; Takahashi, T; Ido, T ^[1]

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1. Tohoku Univ., Sendai (Japan)

The relationship between 3,4-dihydroxy-2-({sup 18}F)fluoro-L-phenylalanine (2-({sup 18}F)FDOPA) uptake and melanogenesis was studied using mice bearing two B16 melanomas: B16-F1 has a higher melanin synthesis ability and a slower growing rate than the higher metastatic B16-F10. A significantly higher 2-({sup 18}F)FDOPA uptake by B16-F1 than by B16-F10 and a reverse relationship for the uptake of ({sup 14}C) 2-deoxy-2-fluoro-D-glucose and ({sup 3}H)thymidine were observed 1 hr postinjection. F1-to-F10 ratios of both the 2-({sup 18}F)FDOPA uptake and the acid-insoluble radioactivity increased to about 5 at 6 hr, which paralleled the melanin content. FM3A mammary carcinoma showed a 2-({sup 18}F)FDOPA uptake similar to the B16-F10 but without the acid-insoluble radioactivity. With D,L-DOPA loading, a 55% decreased uptake by FM3A 1 hr postinjection was significantly greater than the 20% reduction in both melanomas. O-Methylated 2-({sup 18}F)FDOPA was a predominant acid-soluble metabolite in all tumors. Whole-body autoradiography discriminated the two melanomas clearly. 2-({sup 18}F)FDOPA may be a promising tracer for the selective imaging of melanogenesis.

• OSTI ID: 5893995
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:1; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIAGNOSIS
DISEASES
DRUGS
EFFICIENCY
EXPERIMENTAL NEOPLASMS
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
IMAGE PROCESSING
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MELANOMAS
METASTASES
MICE
MONOSACCHARIDES
NEOPLASMS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROCESSING
PYRIMIDINES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RIBOSIDES
RODENTS
SACCHARIDES
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES