Alveolar macrophage mediated pulmonary clearance suppressed by drug-induced phospholipidosis
Journal Article
·
· Exp. Lung Res.; (United States)
Drug-induced phopholipidosis in rats treated with chlorphentermine (CP) for 4-7 days suppressed totally alveolar pulmonary clearance in the first days after a TiO/sub 2/ aerosol exposure. Reversing phospholipidosis by treatment interruption led to a recovery of particle clearance. Morphological observations indicated that ''foam cells'' contained less TiO/sub 2/ particles than alveolar macrophages (AM) of control rats. Clearance of ZnO particles which seems not to be mediated by AM was not affected by CP treatment. A grand average retention curve based on data from control groups of past experiments suggests that alveolar clearance of TiO/sub 2/ particles has a phase 1 (T/sub 1///sub 2/ = 7 days) lasting about 2 weeks and a phase 2 (T/sub 1///sub 2/ = 69 days). The results with drug-induced phospholipidosis suggest that phase 1 is pratically totally AM-mediated. Drug-induced phospholipidosis is a promising method for the study of AM involvement in defensive functions.
- Research Organization:
- Univ. of Rochester, NY
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5893633
- Journal Information:
- Exp. Lung Res.; (United States), Journal Name: Exp. Lung Res.; (United States) Vol. 4; ISSN EXLRD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL HALF-LIFE
BODY
CHALCOGENIDES
CLEARANCE
CONNECTIVE TISSUE CELLS
ESTERS
EXCRETION
INHIBITION
LIPIDS
LUNG CLEARANCE
LUNGS
MACROPHAGES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
PHOSPHOLIPIDS
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TITANIUM COMPOUNDS
TITANIUM OXIDES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
ZINC COMPOUNDS
ZINC OXIDES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL HALF-LIFE
BODY
CHALCOGENIDES
CLEARANCE
CONNECTIVE TISSUE CELLS
ESTERS
EXCRETION
INHIBITION
LIPIDS
LUNG CLEARANCE
LUNGS
MACROPHAGES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHAGOCYTES
PHOSPHOLIPIDS
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TITANIUM COMPOUNDS
TITANIUM OXIDES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
ZINC COMPOUNDS
ZINC OXIDES