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Benzophenanthridines. V. Investigation of the Rodionov-Suvorov scheme. Synthesis of 3,3-diethoxycarbonyl-2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-tetralone

Journal Article · · J. Org. Chem. USSR (Engl. Transl.); (United States)
OSTI ID:5887282

Triethyl 1,3-bis(3,4-dimethoxyphenyl)propane-1,2,2-tricarboxylate was synthesized by the alkylation of the lithium enolate of ethyl homoveratrate with /alpha/-bromo(3,4-dimethoxybenzyl)malonic ester. It was converted by intramolecular acylation, catalyzed by BF/sub 3/ /times/ OEt/sub 2/, into the ACD synthon for the total synthesis of benzo(c)-phenanthridine alkaloids by the Rodionov-Suvorov scheme, i.e., 3,3-diethoxy-carbonyl-2-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-tetralone. The structure of the synthesized substances agrees well with the data from elemental analysis and IR, /sup 1/H NMR, and mass spectra.

Research Organization:
D.I. Mendeleev Moscow Chemical Technology Institute (USSR)
OSTI ID:
5887282
Journal Information:
J. Org. Chem. USSR (Engl. Transl.); (United States), Journal Name: J. Org. Chem. USSR (Engl. Transl.); (United States) Vol. 23:9; ISSN JOCYA
Country of Publication:
United States
Language:
English

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