Identification and comparative risk assessment of airborne carcinogens from combustion sources
The identification and assessment of airborne carcinogens has been significantly advanced by the use of short-term genetic bioassays. Bioassay-directed fractionation coupled with new organic characterization methods has provided the tools needed to more efficiently identify potential carcinogens in complex combustion emissions and urban air samples. These studies have shown that a significant portion of the mutagenicity is found in fractions more polar than polynuclear aromatic hydrocarbons (PAHs). New mass-spectrometry techniques have been developed to identify and quantify the more polar mutagens in these samples. The comparative mutagenicity and carcinogenicity of a series of combustion emissions has been assessed using dose-response studies in bacteria, mammalian cells and rodents. This data base has been used to develop a comparative potency risk assessment methodology for a series of combustion emissions.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5886911
- Report Number(s):
- PB-86-145786/XAB; EPA/600/D-86/013
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
AIR POLLUTION
ANIMALS
AROMATICS
BACTERIA
BIOASSAY
CARCINOGENS
COMBUSTION PRODUCTS
DISTILLATION
GAS ANALYSIS
HYDROCARBONS
INDUSTRIAL MEDICINE
INDUSTRIAL WASTES
MAMMALS
MASS SPECTROSCOPY
MEDICINE
MICROORGANISMS
MUTAGENS
ORGANIC COMPOUNDS
POLAR COMPOUNDS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
SAMPLING
SEPARATION PROCESSES
SPECTROSCOPY
URBAN AREAS
VERTEBRATES
WASTES