Mutagenicity in Salmonella of nitroorganic compounds in extracts of fly ash from a lignite-fired atmospheric fluidized-bed combustor

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530599· OSTI ID:5885214

Remsen, J F; Harris, W R

The mutagenicity of a benzene/methanol extract of fly ash from an atmospheric fluidized-bed combustor burning Beulah, ND, lignite was tested in Salmonella. Six strains were used, including three that were mutants in a nitroreductase gene locus. The numbers of revertants from his/sup -/ to his/sup +/ as a function of the amount of fly ash extracted were determined. The results showed that the major mutagens in the crude extract were nitro compounds, from the fact that reversion rates in the nitroreductase-deficient strains were significantly lower than in the parent strains from which they were derived. The responses of the three parental strains, TA1538, TA98, and TA100, were quite similar; thus no conclusions could be made about frameshift versus base-substitution mutagens. Mutagenicity of 15 fractions of the extract was also tested, and one major peak of activity was detected. This activity eluted from a high-performance liquid chromatograph outside the range of retention times associated with mononitro-aromatics. No further identification of specific nitroorganic compounds has been made. 27 references, 2 figures, 4 tables.

• Research Organization: Univ. of California, Davis
• DOE Contract Number: AC03-76SF00472
• OSTI ID: 5885214
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 14:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ASHES
BACTERIA
BROWN COAL
CARBONACEOUS MATERIALS
CHEMICAL REACTIONS
COAL
COMBUSTION
COMBUSTORS
COMPARATIVE EVALUATIONS
DATA
ENERGY SOURCES
ENZYMES
EXPERIMENTAL DATA
FLUIDIZED-BED COMBUSTORS
FLY ASH
FOSSIL FUELS
FUELS
INFORMATION
LIGNITE
MATERIALS
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NITRO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDATION
OXIDOREDUCTASES
RESIDUES
SALMONELLA
SCREENING
THERMOCHEMICAL PROCESSES
WASTES