Effect of programmed ventricular stimulation on myocardial lactate extraction in patients with and without coronary artery disease

Journal Article · Fri Jan 31 23:00:00 EST 1986 · Am. Heart J.; (United States)

DOI:https://doi.org/10.1016/0002-8703(86)90136-5· OSTI ID:5883225

Morady, F; DiCarlo, Jr, L A; Krol, R B; de Buitleir, M; Nicklas, J M; Annesley, T M

The arterial-coronary sinus lactate difference was measured in 17 patients after each step of a programmed ventricular stimulation protocol consisting of single, double, and triple extrastimuli, first at a basic drive cycle length of 600 msec, then at 400 msec, with an inter-train interval of 4 seconds. Four patients had no structural heart disease, four had an idiopathic dilated cardiomyopathy, and nine had coronary artery disease with a significant stenosis in at least one branch of the left coronary artery. Net myocardial lactate production during programmed ventricular stimulation was observed in three patients with coronary artery disease, but not in any patient without coronary artery disease. Among the patients who had coronary artery disease, net myocardial lactate production generally occurred in the patients who had more severe coronary artery disease. Exercise-induced ischemia, as demonstrated by a stress thallium-201 test, did not correlate with myocardial lactate production during programmed ventricular stimulation. Programmed ventricular stimulation, with a stimulation protocol typically used in many electrophysiology laboratories, is capable of inducing myocardial ischemia in at least some patients who have coronary artery disease. This finding suggests that myocardial ischemia may potentially influence the results of programmed ventricular stimulation in some patients with coronary artery disease.

• Research Organization: Univ. Hospitals, Ann Arbor, MI
• OSTI ID: 5883225
• Journal Information: Am. Heart J.; (United States), Journal Name: Am. Heart J.; (United States) Vol. 2; ISSN AHJOA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BIOSYNTHESIS
BLOOD VESSELS
BODY
CARBOXYLIC ACID SALTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELECTROPHYSIOLOGY
HEART
HEAVY NUCLEI
IMAGES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LACTATES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STIMULATION
SYNTHESIS
THALLIUM 201
THALLIUM ISOTOPES
VASCULAR DISEASES