Anaplastic astrocytoma following radiation for a glomus jugulare tumor
Evaluation of radiation therapy for a given neoplasm includes consideration of possible treatment complications as well as potential benefit. A 43-year old male with a glomus jugulare tumor of the right middle ear had received 4480 rads to the right middle and inner ear and temporal bone. Eight years later, he developed an anaplastic astrocytoma of the right cerebellar hemisphere. At this time a third neoplasm, a left carotid body tumor, was demonstrated angiographically. Although radiation can be implicated in the genesis of the glial neoplasm, the presence of two neural crest derived tumors suggests that a lowered threshold for neoplastic transformation in neuroectodermal cells may have been an additional factor. Long-term follow-up of large numbers of patients with glomus jugulare tumors will be necessary to determine if multiple paragangliomas predispose to radiation-associated gliomas.
- Research Organization:
- Univ. of Texas, San Antonio
- OSTI ID:
- 5882693
- Journal Information:
- Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:6; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBELLUM
DELAYED RADIATION EFFECTS
DISEASES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEAD
IONIZING RADIATIONS
IRRADIATION
LOCAL IRRADIATION
MEDICINE
MUTATIONS
NEOPLASMS
NERVE CELLS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ONCOGENIC TRANSFORMATIONS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
SOMATIC CELLS
THERAPY
VESTIBULAR APPARATUS