Renal brush-border Na/sup +/-H/sup +/ exchange activity in the aging rat

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Am. J. Physiol.; (United States)

OSTI ID:5879248

Kinsella, J L; Sacktor, B

Amiloride-sensitive Na/sup +/-H/sup +/ exchange activity in brush-border membrane vesicles isolated from male rat proximal tubules was decreased in the senescent rat (24 mo) compared with the young adult (6 mo). There was no significant loss in Na/sup +/-H/sup +/ exchange activity in the kidneys of animals between 6 and 18 mo of age. Amiloride-insensitive /sup 22/Na/sup +/ uptake and the rate of pH gradient dissipation were not altered during aging. The decrease in sodium-dependent (/sup 32/P) phosphate transport preceded the decline in Na/sup +/-H/sup +/ exchange activity by at least 6 mo. Sodium-dependent D-(/sup 3/H) glucose transport was not significantly altered during aging. Thus various renal plasma membrane transport functions were affected differently in the aging rat. The decrease in Na/sup +/-H/sup +/ exchange activity during aging contrasted with the increase in exchange activity reported previously in acute ablation models of chronic renal failure.

• Research Organization: National Institutes of Health Gerontology Research Center, Baltimore, MD
• OSTI ID: 5879248
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:4; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ALDEHYDES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CATIONS
CELL CONSTITUENTS
CELL MEMBRANES
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
ELEMENTARY PARTICLES
FERMIONS
GLUCOSE
HADRONS
HEXOSES
IONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
MALES
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
MONOSACCHARIDES
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PH VALUE
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROTONS
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SODIUM 22
SODIUM COMPOUNDS
SODIUM ISOTOPES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES