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Altered in vitro uptake of the radiolabelled antiviral imaging probe E-5-(2-125-iodovinyl)-2'-deoxyuridine following administration of acyclovir

Journal Article · · J. Med. Virol.; (United States)
; ; ; ;

Current developments in the use of radiolabelled antiviral drugs as specific probes for virus-infected cells in vivo may allow the specific neuroradiological diagnosis of herpes encephalitis. As blind therapy with the antiviral drug acyclovir may precede specific neuroradiological diagnosis, the aim of the present study was to investigate whether or not acyclovir interferes with the uptake of the radioprobe E-5-(2-125-Iodovinyl)-2'-deoxyuridine (rIVDU) by virus-infected cells in vitro. Acyclovir treatment (0.1 to 10 micrograms/ml) was shown to increase initial radioprobe uptake by virus-infected cells. However, with continued incubation in the presence of acyclovir, intracellular radioactivity decreased to a level not significantly different from that associated with noninfected cells. A mechanism to explain these results is proposed. It was concluded that concurrent acyclovir therapy could interfere with neuroradiological diagnosis using rIVDU, although this may not occur with all the candidate radioprobes currently under investigation.

Research Organization:
Univ. of Manchester (England)
OSTI ID:
5877833
Journal Information:
J. Med. Virol.; (United States), Journal Name: J. Med. Virol.; (United States) Vol. 28:1; ISSN JMVID
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTI-INFECTIVE AGENTS
ANTIMETABOLITES
ANTIMICROBIAL AGENTS
AZINES
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
DATA COVARIANCES
DAYS LIVING RADIOISOTOPES
DEOXYURIDINE
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOISOTOPES
RADIOPHARMACEUTICALS
REACTION KINETICS
RIBOSIDES
UPTAKE
URACILS
VIRAL DISEASES