Influence of organotins on rat platelet aggregation mechanisms

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80019-6· OSTI ID:5877202

Knowles, C O; Johnson, T L

The effects of ten organotins on rat platelet aggregation mechanisms were examined. Bis(tri-n-butyltin)oxide was the most potent inhibitor of both ADP- and collagen-induced aggregation, and it was the only organotin that directly induced aggregation. It also increased the latent period for induction of aggregation by collagen. Triphenyltin hydroxide was a weak inhibitor of both ADP- and collagen-induced aggregation. However, in contrast to bis(tri-n-butyltin)oxide, it decreased the latent period for collagen-induced aggregation. A similar effect also was observed with diphenyltin dichloride, phenyltin trichloride, and cyhexatin. Tri-n-butyltin chloride and tetra-n-butyltin demonstrated specificity in their action since aggregation induced by ADP but not collagen was inhibited. Tri-n-propyltin chloride, trimethyltin chloride, and fenbutatin oxide were without discernible effect on rat platelet aggregation.

• Research Organization: Univ. of Missouri, Columbia
• OSTI ID: 5877202
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 39:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLOMERATION
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RATS
RODENTS
TIN COMPOUNDS
TOXICITY
VERTEBRATES