In-111-labeled platelets: Role of spleen in their kinetics and distribution

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5875476

Hill-Zobel, R L; McCandless, B; Kang, S A; Chikkappa, G; Gannon, S; Danis, E; Tsan, M F

To evaluate the role of the spleen in the kinetics and distribution of platelets, the authors studied 12 normal individuals, 4 patients with splenectomy and normal platelet counts, and 3 patients with splenomegaly and slightly reduced platelet counts. Using In-111-oxine labeled platelets and computer-assisted gamma camera imaging, platelet survival and organ distribution were determined. The mean platelet survival time (MPST) was calculated using the multiple-hit model, which fit the survival curves best. Organ accumulation of In-111-platelets was quantified using the transmission images and geometric mean of anterior and posterior images. The results are presented in this paper. The initial recovery of In-111-platelets was almost 100% in asplenics while it was 29% in hypersplenic subjects. The MPST of asplenics was slightly longer than that of normals, but was not significantly different, while the MPST of hypersplenics was significantly reduced. More than 80% of In-111-platelets was sequestered in the liver of asplenic subjects, while more than 80% was sequestered in the spleen of hypersplenic subjects. These results suggest the spleen plays as important role in the kinetics and distribution of platelets, and the reduced platelet counts in patients with splenomegaly is due to splenic pooling as well as reduced platelet survival.

• Research Organization: VA Medical Center and Albany Medical College, Albany, NY
• OSTI ID: 5875476
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISTRIBUTION
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED POOL TECHNIQUES
LABELLING
LIVER
MATERIALS
MATHEMATICAL MODELS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXINE
PATIENTS
PYRIDINES
QUINOLINES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SPLEEN
SPLENECTOMY
SURGERY
SURVIVAL TIME
TISSUE DISTRIBUTION
TRACER TECHNIQUES
USES