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Heteronuclear NMR studies of cobalamins. 11. sup 15 N NMR studies of the axial nucleotide and amide side chains of cyanocobalamin and dicyanocobamides

Journal Article · · Inorganic Chemistry; (USA)
DOI:https://doi.org/10.1021/ic00349a001· OSTI ID:5873068
; ;  [1]; ;  [2];  [3]
  1. Mississippi State Univ., Mississippi State (USA)
  2. Univ. of Texas, Arlington (USA)
  3. Univ. of Alabama, Tuscaloosa (USA)

Spectroscopic and thermodynamic evidence for the structure of cobalamines and dicyanocobalamin (CN){sub 2}Cbl have been previously reported. The structure indicated the occurrence of the so-called tuck-in species. Further observations and characterization of the tuck-in species of (CN){sub 2}Cbl by {sup 15}N NMR spectroscopy are presented herein. These results represent the first observation of the {sup 15}N NMR spectrum of benzimidazole nucleotide of cobalamins. The first NMR observation of the amide protons of cobalamins and their connectivity to the amide nitrogens are also reported. 50 refs., 2 figs., 2 tabs.

OSTI ID:
5873068
Journal Information:
Inorganic Chemistry; (USA), Journal Name: Inorganic Chemistry; (USA) Vol. 29:24; ISSN 0020-1669; ISSN INOCA
Country of Publication:
United States
Language:
English