Computer assisted biokinetic studies of radiopharmaceuticals in animals and humans

Conference · Mon Jun 01 04:00:00 EDT 1981 · HHS Publ. (FDA) (U.S.); (United States)

OSTI ID:5872900

Darte, L; Persson, B R.R.; Strand, S E; Olsson, C G

The labelling of plasmin with technetium-99m was first studied in our department. A stable kit is obtained by lyophilizing plasmin (NOVO Industry A/S, Denmark), stannous chloride and sodium chloride at low pH in nitrogen atmosphere. Pertechnetate is added to this kit and incubated during one hour. The labelling yield of /sup 99m/Tc-plasmin recorded by the use of gel chromatography column scanning averaged 85%. Artificial thrombi were formed in the jugular vein of rabbits by trapping iron particles injected into an ear vein. The kinetics of /sup 99m/Tc-plasmin uptake by the thrombi was studied with dynamic scintillation camera measurements. To study the whole body distribution in patients with a scintillation camera we used about 80 MBq (approx. 2 mCi) of /sup 99m/Tc-plasmin. The highest activity uptake 1 to 2 h after injection was in liver and spleen (35%) and the activity in the legs was about 15%. The absorbed dose per unit of administered activity in whole body was estimated to be about 7 ..mu..Gy/MBq (25 mrad/mCi). In routine clinical measurements about 10 to 30 MBq (0.3 to 0.9 mCi) /sup 99m/Tc-plasmin was injected and measurements were performed with a hand detector. This method is now used routinely in several hospitals of southern Sweden and in London for the diagnosis of deep venous thrombosis.

• Research Organization: Lund Univ., Lasarettet, Sweden
• OSTI ID: 5872900
• Report Number(s): CONF-801082-
• Conference Information: Journal Name: HHS Publ. (FDA) (U.S.); (United States) Journal Volume: 81-8166
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
COMPUTER-AIDED DESIGN
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DOSES
DRUGS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LEGS
LIMBS
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SPLEEN
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THROMBOSIS
TISSUE DISTRIBUTION
USES
VASCULAR DISEASES
VEINS
YEARS LIVING RADIOISOTOPES