Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora

Journal Article · Thu Aug 30 00:00:00 EDT 1984 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(84)90407-8· OSTI ID:5871679

Cerniglia, C E; Howard, P C; Fu, P P; Franklin, W

Anaerobic bacterial suspensions from human and rat feces and intestinal contents, and pure cultures of anaerobic bacteria metabolized 1-nitropyrene and 6-nitrobenzo(a)pyrene to 1-aminopyrene and 6-aminobenzo(a)pyrene, respectively. The metabolites were isolated by reversed-phase high performance liquid chromatography and identified by comparison of their chromatographic and mass spectral properties with those of authentic compounds. The results suggest that anaerobic intestinal bacteria could play a significant role in the metabolism of potentially carcinogenic nitropolycyclic aromatic hydrocarbons. 28 references, 4 figures, 1 table.

• Research Organization: National Center for Toxicological Research, Jefferson, AK
• OSTI ID: 5871679
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 123:1; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BACTERIA
BENZOPYRENE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARCINOGENS
CHROMATOGRAPHY
CONDENSED AROMATICS
FECES
HYDROCARBONS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MAN
MATERIALS
METABOLISM
METABOLITES
MICROORGANISMS
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
RATS
RODENTS
SEPARATION PROCESSES
VERTEBRATES
WASTES