Development of rat telencephalic neurons after prenatal x-irradiation
Telencephalic neurons of rats, irradiated at day 15 of gestation with 125 R, develop synaptic connections on dendrites during maturation which appear to be normal spines in Golgi-stained light microscope preparations. At six weeks of postnatal age both control and irradiated rats have spiny dendritic processes on cortical pyramidal cells and caudate Golgi type II neurons. However, when the rats are 6 months old the irradiated rats have more neurons with beaded dendritic processes that lack spines or neurons and are likely to be degenerating neurons. The apparently normal development of the neurons followed by degeneration in the irradiated rat has a parallel in previous reports of the delayed hyperactivity which develops in rats irradiated on the fifteenth gestational day.
- OSTI ID:
- 5870267
- Journal Information:
- J. Environ. Sci. Health, Part C; (United States), Journal Name: J. Environ. Sci. Health, Part C; (United States) Vol. 13:2; ISSN JEHSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550800 -- Morphology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CYTOLOGY
DOSES
EMBRYOS
IRRADIATION
MAMMALS
MORPHOLOGICAL CHANGES
MORPHOLOGY
NERVE CELLS
NERVOUS SYSTEM
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RATS
RODENTS
SOMATIC CELLS
VERTEBRATES