Inhibition of acetaminophen activation by ethanol and acetaldehyde in liver microsomes

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90479-U· OSTI ID:5863099

Sato, Chifumi; Liu, Jian; Miyakawa, Happei; Nouchi, Toshihiko; Tanaka, Yujiro; Uchihara, Masakatsu; Marumo, Fumiaki ^[1]

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1. School of Allied Health Sciences, Tokyo (Japan) Tokyo Medical and Dental Univ. (Japan)

Mechanisms of the inhibitory effect of ethanol on acetaminophen hepatotoxicity are controversial. The authors studied the effects of ethanol and acetaldehyde, and oxidative metabolite of ethanol, on NADHP-dependent acetaminophen-glutathione conjugate production in liver microsomes. Ethanol at concentrations as low as 2mM prevented the conjugate production noncompetitively. Acetaldehyde also inhibited acetaminophen-glutathione conjugate production at concentrations as low as 0.1 mM that is comparable with those observed in vivo after social drinking. Acetaldehyde may be involved in ethanol-induced inhibition of acetaminophen hepatotoxicity.

• OSTI ID: 5863099
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:24; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETALDEHYDE
ALCOHOLS
ALDEHYDES
ANALGESICS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
ETHANOL
GLANDS
HYDROXY COMPOUNDS
INHIBITION
LIVER
METABOLISM
METABOLITES
MICROSOMES
ORGANIC COMPOUNDS
ORGANS
RIBOSOMES