Technetium-99m(Sn/sup 2 +/)pyrophosphate in ischemic and infarcted dog myocardium in early stages of acute coronary occlusion: histochemical and tissue-counting comparisons

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5855469

Bianco, J A ^[1]; Kemper, A J; Taylor, A; Lazewatsky, J; Tow, D E; Khuri, S F

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1. Univ. of Massachusetts, Worcester

The pattern of accumulation of Tc-99m(Sn/sup 2 +/)pyrophosphate (Tc-99m PPi) in myocardial tissue of dogs during the early stages of acute occlusion of the left anterior descending coronary artery has been investigated. Three groups were studied after: (a) 40 min occlusion followed by 6 h reperfusion (n = 6); (b) 6 h occlusion followed by one hour reperfusion (n = 5); and (c) 7h occlusion with no reperfusion (n = 4). Areas of myocardial infarction were defined with triphenyl-tetrazolium chloride (TTC) staining, and blood flow was determined with 9-..mu.. radioactive microspheres. In Group C uptake in infarcted and peri-infarct areas was not enhanced, most likely owing to low flow. In Group B, with late reperfusion, Tc-99m PPi sequestration was increased in both infarcted and peri-infarcted tissues. In Group A, areas ischemic during occlusion but with normal flow and viability by TTC after 6 h of reperfusion showed significant uptake of Tc-99m PPi (twice the uptake of nonischemic regions).

• OSTI ID: 5855469
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
HALIDES
HALOGEN COMPOUNDS
HEART
HETEROCYCLIC COMPOUNDS
HISTOLOGY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TETRAZOLES
TETRAZOLIUM
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES