Imaging of lymphoid structures with indium-111-labeled lymphocytes
Journal Article
·
· Invest. Radiol.; (United States)
The ability of indium-111 (/sup 111/In)-oxine-labeled syngeneic lymphocytes to migrate normally and their suitability for imaging both normal lymphoid structures and those with metastatic disease were assessed. Sixty-two ACI rats were studied, 34 of which received injections in the left foot pad with 1 X 10(6) syngeneic H-4-II-E hepatoma cells nine to 44 days before imaging. Most animals were bearing palpable tumors when imaged. In 53 experiments, 1-6 X 10(8) /sup 111/In-oxine-labeled lymphocytes with a labeling concentration of 5-80 microCi/10(8) cells were injected intravenously. Gamma camera images were obtained 22 hours later. After the last image, the animals were killed. The lymph nodes, liver, spleen, lungs, and left femur were dissected, and the recovered radioactivity was determined in a gamma well counter. Lymph nodes could be partially or completely visualized in 70% of the animals (15 tumor-bearing and 16 normal out of 44 technically satisfactory experiments). Large metastatic nodes were seen clearly. Lymphocytes labeled with /sup 111/In-oxine exhibited a normal migration from blood to lymph nodes.
- Research Organization:
- Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts
- OSTI ID:
- 5855129
- Journal Information:
- Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 18:1; ISSN INVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METASTASES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
TISSUE DISTRIBUTION
TUMOR CELLS
USES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METASTASES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
TISSUE DISTRIBUTION
TUMOR CELLS
USES
VERTEBRATES