Chronic graft-versus-host disease in the rat radiation chimera. III. Immunology and immunopathology in rapidly induced models
Although chronic graft-versus-host disease (GVHD) frequently develops in the long-term rat radiation chimera, we present three additional models in which a histologically similar disease is rapidly induced. These include adoptive transfer of spleen and bone marrow from rats with spontaneous chronic GVHD into lethally irradiated rats of the primary host strain; sublethal irradiation of stable chimeras followed by a booster transplant; and transfer of spleen cells of chimeras recovering from acute GVHD into second-party (primary recipient strain) or third-party hosts. Some immunopathologic and immune abnormalities associated with spontaneous chronic GVHD were not observed in one or more of the induced models. Thus, IgM deposition in the skin, antinuclear antibodies, and vasculitis appear to be paraphenomena. On the other hand, lymphoid hypocellularity of the thymic medulla, immaturity of splenic follicles, and nonspecific suppressor cells were consistently present in the long term chimeras, and in all models. These abnormalities therefore may be pathogenetically important, or closely related to the development of chronic GVHD.
- Research Organization:
- Department of Pathology, John Hopkins Medical Institution, Baltimore, Maryland
- OSTI ID:
- 5853168
- Journal Information:
- Transplantation; (United States), Vol. 35:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Intrathymic T cell differentiation in radiation bone marrow chimeras and its role in T cell emigration to the spleen. An immunohistochemical study
Antilymphocytic antibodies and marrow transplantation. VIII. Recipient conditioning with Clq-affine monoclonal anti-pan T antibodies prevents GVHD in homozygous fully mismatched mice
Related Subjects
BONE MARROW
TRANSPLANTS
RADIATION CHIMERAS
GRAFT-HOST REACTION
IMMUNOLOGY
SPLEEN
BIOLOGICAL RADIATION EFFECTS
IMMUNOGLOBULINS
PATHOLOGY
RATS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHIMERAS
GLOBULINS
HEMATOPOIETIC SYSTEM
MAMMALS
MOSAICISM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals