Cysteamine blocks somatostatin secretion without altering the course of insulin or glucagon release. A new model for the study of islet function

Journal Article · Thu Mar 31 23:00:00 EST 1983 · Diabetes; (United States)

DOI:https://doi.org/10.2337/diab.32.4.377· OSTI ID:5852609

Sorenson, R L; Grouse, L H; Elde, R P

Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated animals failed to secrete somatostatin in response to glucose. Cysteamine treatment was without effect on insulin and glucagon release under the conditions tested. The isolated perfused pancreas from the cysteamine-treated rat provides a model for further investigations into regulation of islet hormone release in the absence of stimulated somatostatin release.

• Research Organization: Department of Anatomy, University of Minnesota Medical School, Minneapolis
• OSTI ID: 5852609
• Journal Information: Diabetes; (United States), Journal Name: Diabetes; (United States) Vol. 32:4; ISSN DIAEA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
DIGESTIVE SYSTEM
DRUGS
ENDOCRINE GLANDS
GLANDS
GLUCAGON
HORMONES
INHIBITION
INSULIN
MAMMALS
MEA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PANCREAS
PEPTIDE HORMONES
PEPTIDES
PHYSIOLOGY
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SOMATOSTATIN
THIOLS
VERTEBRATES