Malignant lymphoma. Prognostic factors and response to treatment of 473 patients at the National Cancer Institute

Journal Article · Wed Dec 15 04:00:00 EST 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19821215)50:12<2708::AID-CNCR2820501203>3.0.CO;2-G· OSTI ID:5850181

Anderson, T ^[1]; DeVita, Jr, V T; Simon, R M; Berard, C W; Canellos, G P; Garvin, A J; Young, R C

---

1. Medical Coll. of Wisconsin, Milwaukee

Treatment results were reviewed in 473 consecutively staged and treated patients at the National Cancer Institute over a 22-year period from 1953 to 1975. Responses correlated with histologic pattern and stage of disease. Complete responses to radiotherapy were frequent in nodular lymphoma patients. Similar treatment regimens were less effective in diffuse lymphoma patients. Using chemotherapy or combined modality approaches, complete responses were obtained in a high proportion of advanced nodular disease patients. Patients with nodular lymphoma tend to have higher complete response rates and longer survivals than their counterparts with diffuse histologic types. Patients with nodular lymphocytic lymphoma had a better survival than those with mixed or ''histiocytic'' histologic types. Patients with diffuse well differentiated lymphocytic lymphoma survived significantly longer than patients with other diffuse histologic types. Percentage and prominence of nodularity were not of prognostic significance in those patients with combined nodular and diffuse patterns of disease. When compared by histologic type, patient sex did not appear to be an important prognostic factor. The presence of B-symptoms was associated with a poorer survival in patients with nodular disease and in patients with diffuse disease. Over the years of this study, survival appears to have improved in each histologic subtype except diffuse poorly differentiated lymphoma.

• OSTI ID: 5850181
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:12; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
DIAGNOSIS
DISEASES
DOCUMENT TYPES
DOSES
EVALUATION
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
REVIEWS
SURVIVAL TIME
THERAPY