Effects of environmentally differential rearing upon maze performance in prenatally irradiated microcephalic rats

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Teratology; (United States)

DOI:https://doi.org/10.1002/tera.1420260302· OSTI ID:5849160

Seo, M L; Inouye, M; Kiyono, S; Shibagaki, M

Pregnant rats received 100 rads of X-irradiation on day 17 of gestation. Control pregnant rats were sham-irradiated on the same gestation day. The male offspring were reared under environmentally enriched, standard colony, and impoverished conditions for 30 days after weaning. Then the Hebb-Williams maze test was carried out. All the prenatally X-irradiated rats were microcephalic: their mean cerebral wet weight was 15.5% less than controls. The effect of X-irradiation was not significant in error scores and running times, whereas the effect of environment was significant in these items; initial and total error scores and running times were decreased in enriched groups compared to impoverished groups in controls as well as in X-irradiated animals.

• Research Organization: Department of Physiology, Institute for Developmental Research, Aichi Prefectural Colony, Japan
• OSTI ID: 5849160
• Journal Information: Teratology; (United States), Journal Name: Teratology; (United States) Vol. 26:3; ISSN TJADA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DIET
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
PERFORMANCE
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
VERTEBRATES
X RADIATION