Hyperplasia of type 2 pneumocytes following 0. 34 ppm nitrogen dioxide exposure: quantitation by image analysis. [Mice]

Journal Article · Wed Sep 01 00:00:00 EDT 1982 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1982.10667584· OSTI ID:5848078

Sherwin, R P; Richters, V

Swiss Webster male mice were exposed to intermittent 0.34 ppm nitrogen dioxide for 6 wk. Quantitative image analysis showed increased Type 2 cell numbers in each of the three lobes measured, with and without adjustment to alveolar wall measurements for lung volume normalization (e.g., P < .037 for Type 2 cell number adjusted to alveolar wall perimeters, combined lobe analysis of variance). The exposed animals dominated the upper quartile ranking of the cell number/alveolar area ratio computations (P < .025), which implied the presence of an especially susceptible subpopulation of animals. The Type 2 cell increase is believed to result from damage and loss of Type 1 cells, the reversibility and progression of which are presently unknown. The data also suggest an increased size of the Type 2 cell, and possibly slight atelectasis and/or edema of the alveolar walls.

• Research Organization: Univ. of Southern California, Los Angeles
• OSTI ID: 5848078
• Journal Information: Arch. Environ. Health; (United States), Vol. 37:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
CELL PROLIFERATION
MICE
SENSITIVITY
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
IMAGE PROCESSING
ANIMALS
BODY
CHALCOGENIDES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PROCESSING
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)