Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens

Journal Article · Tue Oct 01 04:00:00 EDT 1985 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8562185· OSTI ID:5842720

Harris, C C

Scientific opportunities generally arise when two or more research areas converge and/or advances in methodology occur. This occurred at the turn of the 19th century in the field of infectious bacterial and fungal diseases. As we draw near to the 21st century, research in the laboratory is providing us with both critical information on mechanisms of carcinogenesis and new technological advancements, including those in immunology, biochemistry, and molecular biology. Investigations in the field of epidemiology have clearly demonstrated the importance of environmental exposure to carcinogens and have identified populations at high cancer risk. It is now practical to integrate laboratory determinations into classic epidemiological approaches. Several markers, e.g., carcinogen-DNA adducts, related to tumor initiation and perhaps to tumor conversion, are currently being evaluated. We also need to develop indicators of tumor promotion and progression. The potential of biochemical and molecular epidemiology to predict cancer risk in an individual prior to the onset of clinically evident cancer provides an exciting new opportunity in cancer research and prevention.

• Research Organization: National Cancer Institute, Bethesda, MD
• OSTI ID: 5842720
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States); ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ANIMALS
BIOLOGICAL INDICATORS
BLADDER
BODY
BRONCHI
CARCINOGENS
DIGESTIVE SYSTEM
DISEASES
DNA
DNA ADDUCTS
ENDOCRINE GLANDS
ENVIRONMENTAL EXPOSURE
ESOPHAGUS
GLANDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MAN
MICE
MONITORING
MUTAGENS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PRIMATES
PROMOTERS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RESPIRATORY SYSTEM
RODENTS
TRACER TECHNIQUES
TUMOR PROMOTERS
URINARY TRACT
VERTEBRATES