Post-irradiation glucan administration enhances the radioprotective effects of WR-2721. Scientific report
Technical Report
·
OSTI ID:5842482
Based on murine survival studies, endogeneous hemopoietic spleen colony formation (E-CFU), and recovery of bone marrow and splenic granulocyte-macrophage colony-forming cells(GM-CFC), it was demonstrated that the postirradiation administration of glucan, an immunomodulator and hemopoietic stimulant, enhances the radioprotective effects of WR-2721. These effects appeared to depend on the sequential cell protection mediated by WR-2721 and hemopoietic repopulation mediated by glucan.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5842482
- Report Number(s):
- AD-A-207915/0/XAB; AFRRI-SR-89-10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
AUGMENTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DOCUMENT TYPES
DRUGS
HEMATOPOIETIC SYSTEM
IMMUNOTHERAPY
INJURIES
ORGANS
PROGRESS REPORT
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RECOVERY
THERAPY
TISSUES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
AUGMENTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DOCUMENT TYPES
DRUGS
HEMATOPOIETIC SYSTEM
IMMUNOTHERAPY
INJURIES
ORGANS
PROGRESS REPORT
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RECOVERY
THERAPY
TISSUES