Routine synthesis of carbon-11-carboxyl-labeled L-dopa

Journal Article · Thu Oct 01 00:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:5841507

Adam, M J; Grierson, J R; Ruth, T J; Pedersen, K; Pate, B D

Carbon-11-carboxyl-labeled L-dopa has been synthesized by the modified Bucherer-Strecker method. The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid. The entire procedure was performed in a remotely operated system which gave the product in 28% radiochemical yield (decay corrected) in an overall synthesis time of 55-60 min.

• Research Organization: UBC/TRIUMF Program on Positron Emission Tomography, Vancouver
• OSTI ID: 5841507
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:10; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL PREPARATION
CHROMATOGRAPHY
DRUGS
EVEN-ODD NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
MINUTES LIVING RADIOISOTOPES
NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SYNTHESIS