Redox cycling of radical anion metabolites of toxic chemicals and drugs and the Marcus Theory of electron transfer

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.9087237· OSTI ID:5840195

Mason, R P ^[1]

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1. National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)

A wide variety of aromatic compounds are enzymatically reduced to form anion free radicals that generally contain one more electron than their parent compounds. In general, the electron donor is any of a wide variety of flavoenzymes. Once formed, these anion free radicals reduce molecular oxygen to superoxide and regenerate the parent compound unchanged. The net reaction is the oxidation of the flavoenzyme's coenzymes and the reduction of molecular oxygen. This catalytic behavior has been described as futile metabolism or redox cycling. Electron transfer theory is being applied to these reactions and, in some cases, has successfully correlated V{sub max} and K{sub m} with the reduction potentials of the aromatic compounds.

• OSTI ID: 5840195
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 87; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANIONS
AROMATICS
AZO COMPOUNDS
BINDING ENERGY
BIOCHEMICAL REACTION KINETICS
CHARGED PARTICLES
CHEMICAL REACTIONS
DIAPHORASE
ELECTRON SPIN RESONANCE
ELECTRONS
ELEMENTARY PARTICLES
ENERGY
ENZYMES
FERMIONS
HETEROCYCLIC COMPOUNDS
IONS
ISOALLOXAZINES
KINETICS
LEPTONS
MAGNETIC RESONANCE
MAMMALS
NUCLEOTIDE DEHYDROGENASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDOREDUCTASES
QUINONES
RADICALS
RATS
REACTION KINETICS
REDOX REACTIONS
RESONANCE
RODENTS
SUPEROXIDE DISMUTASE
VALENCE
VERTEBRATES