Cardiovascular sequelae of therapeutic thoracic radiation

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Progress in Cardiovascular Diseases; (USA)

DOI:https://doi.org/10.1016/0033-0620(91)90022-E· OSTI ID:5839024

Arsenian, M A ^[1]

---

1. Univ. of Tennessee, Knoxville (USA)

Mediastinal radiation damages endothelial cells, with resulting loss of capillaries and ischemia at the level of the microcirculation. These changes lead to increases in collagen and proliferation of fibrous tissue throughout the heart. Cardiac dysfunction following radiotherapy is surprisingly common and may be due to pericardial, myocardial, valvular, conduction system, or coronary artery disease. Greater awareness of cardiotoxicity has prompted changes in radiation techniques that appear to reduce clinical cardiovascular complications.135 references.

• OSTI ID: 5839024
• Journal Information: Progress in Cardiovascular Diseases; (USA), Journal Name: Progress in Cardiovascular Diseases; (USA) Vol. 33:5; ISSN 0033-0620; ISSN PCVDA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
CELL PROLIFERATION
CHEST
COLLAGEN
DISEASES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
IRRADIATION
MEDIASTINUM
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PROTEINS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
REVIEWS
SCLEROPROTEINS
SIDE EFFECTS
THERAPY