Concomitant evaluation of efficiency, acute and delayed toxicities of combined treatment of radiation and CDDP on an in vivo model

Journal Article · Fri Feb 01 04:00:00 EST 1991 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(91)90118-N· OSTI ID:5838510

Julia, A M; Canal, P; Berg, D; Bachaud, J M; Daly, N J; Bugat, R ^[1]

---

1. Centre Claudius Regaud, Toulouse (France)

The efficiency, acute and delayed toxicities of different radio-chemotherapeutic combinations were assessed on an in vivo model (Krebs II ascitic carcinoma grafted to female Swiss mice). Mice were given whole abdomen irradiation (WAI) 2.5 to 10 Gy as a single dose (WAI). CDDP was given intraperitoneally at 0.5 to 4 mg/kg dose level, 12 hr before or after WAI. There was a relationship between dose of CDDP and increase of life span (ILS) of mice. However, WAI did not increase the life span. When a single dose of 2 mg/kg CDDP was given prior to a 2.5 Gy WAI, the ILS reached 47%. By contrast, it was only 37% when treatment sequence was reversed. When the WAI dose level was increased to 5 Gy, the ILS was not increased. The jejunal crypt cell number, determined 3 days after the last treatment, was not modified, regardless of the treatment sequence. There was no delayed renal toxicity. The study on the Krebs II ascites model confirms the tumor cell therapeutic potentiation without exacerbation of normal tissue damage.

• OSTI ID: 5838510
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 20:2; ISSN 0360-3016; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
ASCITES TUMOR CELLS
BODY
BODY AREAS
CARCINOMAS
COMBINED THERAPY
DIGESTIVE SYSTEM
DISEASES
DRUGS
EFFICIENCY
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
IN VIVO
INTESTINES
KIDNEYS
LIFE SPAN
MAMMALS
MICE
NEOPLASMS
ORGANS
RODENTS
SMALL INTESTINE
THERAPY
TOXICITY
TUMOR CELLS
VERTEBRATES