Ethanol intake and sup 3 H-serotonin uptake II: A study in alcoholic patients using platelets sup 3 H-paroxetine binding

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90231-Y· OSTI ID:5836769

Daoust, M; Boucly, P ^[1]; Ernouf, D ^[2]; Breton, P ^[3]; Lhuintre, J P

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1. U.F.R. de Medecine et Pharmacie, Saint Etienne du Rouvrary (France)
2. Institut du Medicament, Tours (France)
3. Centre National de Transfusion Sanguine de Rouen (France)

The kinetic parameters of {sup 3}H-paroxetine binding and {sup 3}H-serotonin uptake were studied in platelets of alcoholic patients. There was no difference between alcoholic and non alcoholic subjects in {sup 3}H-paroxetine binding. When binding and {sup 3}H-serotonin uptake were studied, in the same plasma of the same subjects, the Vmax of serotonin uptake was increased in alcoholics. The data confirm the involvement of serotonin uptake system in alcohol dependance and suggest that serotonin uptake and paroxetine binding sites may be regulated independently in this pathology.

• OSTI ID: 5836769
• Journal Information: Life Sciences; (USA), Vol. 48:20; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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